Carrier state of Typhoid fever patient after treatment with chloramphenicol

Treatment of the Typhoid Carrier State with Chloramphenicol *

The efficacy of chloramphenicol: in the treatment of acute typhoid fever is well established.84' 9 l0'1 18 However, treatment of the typhoid carrier state with this antibiotic, for varying periods of time and at dosage levels generally accepted as high, has been unsatisfactory.2 Untoward reactions have also been reported,' 2,6 of which anorexia, nausea, and a bitter taste in the mouth were the ...

Chloramphenicol therapy of typhoid fever.

In a prospective study we compared two different dosage regimens of IV chloramphenicol succinate (100 mg/kg/day and 75 mg/kg/day) in children with culture proven typhoid. Trough and peak blood samples, obtained at 48 hrs, were analysed for free chloramphenicol by high pressure liquid chromatography (HPLC). Although the mean trough (8.8 +/- 7.7 versus 5.4 +/- 2.6 mcg/ml) and peak (19.9 +/- 12.2 ...

[Prevalence of typhoid carriers after treatment with chloramphenicol].

William Budd (1)) anticipating the discovery of the typhoid bacillus by 24 years, probably intuited the existence of carriers when he said that “the first case may be foreign or may be due to the local poison that arises, like a fire from its ashes, as a sleeping legacy from a similar previous outbreak.” At the end of the nineteenth century, Koch demonstrated clearly the role of the human being...

Chloramphenicol and other antibiotics in the treatment of typhoid fever and typhoid carriers.

Amoxycillin in treatment of typhoid fever in patients with haematological contraindications to chloramphenicol.

Thirty adults with proved typhoid fever were treated with amoxycillin 1 g six-hourly by mouth for an average of 14 days because of haematological contraindications to chloramphenicol. Eighteen patients were Egyptian men with the Mediterranean variety of glucose-6-phosphate dehydrogenase deficiency and an enzyme activity in the red cells fanging from 0 to 3%, and 12 patients had a history of sev...